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Business Editors & Health/Medical Writers REDWOOD CITY, Retin a micro prescription calif. –(BW Health Wire)–July 23, 2001 AP Pharma, Inc. Digital photographs, which provide an objective method of evaluating facial shine, were taken at each time interval. The company’s product retin a micro prescription development programs are funded by royalties from topical products currently marketed by pharmaceutical partners, and proceeds from the divestiture of its cosmeceutical product lines. Using its existing cash resources and growing royalty streams, AP Pharma intends to develop and commercialize its families of bioerodible delivery systems for injectable and implantable drug delivery. The most common adverse reactions to RETIN-A MICRO were limited to mild or moderate irritation of the skin. The company’s primary focus is the development and commercialization retin a micro prescription of its bioerodible injectable and implantable systems under the trade name Biochronomer(TM). Upon commercialization, anticipated in the third quarter of 2001, AP Pharma will begin to receive royalties on product sales. (Nasdaq:APPA), a specialty pharmaceutical company, today announced that Canadian drug regulatory authorities have granted retin a micro prescription marketing clearance for Retin-A Micro(R) (tretinoin gel) microsphere, 0. 1% for the treatment of acne. Prescription acne market and is licensed to AP Pharma’s development and marketing partner, Ortho Dermatological, a member of the Johnson & Johnson family of companies. Highlights of the 2001 first quarter included: Michael O’Connell, president and CEO, commented, We have refocused Advanced Polymer Systems as a specialty pharmaceutical company, devoting our resources to the development of ethical pharmaceutical products with longer life cycles and higher margins. The company does not undertake to revise these forward-looking statements to reflect events or circumstances occurring in the future. Photographic analyses showed reductions in facial shine for both treatments, but decreases were greater on the RETIN-A MICRO treated sides. Johnson & Johnson Canada will market the product in Canada under the same U. For further information visit the retin a micro prescription company’s Web site at www. Appharma. Other risks and uncertainties associated with the company’s Retin a micro prescription business and prospects are identified in the company’s filings with the Securities and Exchange Commission. Known as Biochronomer(TM) systems, they are designed for the controlled release of drugs into various sites such as under the skin, in muscle or in the peritoneal cavity and offer potential for use in a broad array of pharmaceutical products. About AP Pharma AP Pharma is a specialty pharmaceutical company focused on the development Retin a micro prescription of ethical (prescription) pharmaceuticals utilizing its proprietary polymer-based drug delivery systems. Initial targeted areas of application for the Company’s drug delivery technology include pain management, inflammation, anti-adhesion and protein delivery applications.