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Evaluation of the Safety and Efficacy of Eszopiclone in Patients With Obstructive Sleep Apnea; Presented Tuesday, June 21, 2005 The results of a randomized, double-blind crossover study evaluating the safety and efficacy of eszopiclone 3 mg in 21 patients with mild-to-moderate obstructive sleep apnea (OSA; a temporary cessation of breathing during sleep) were presented yesterday. But its greatest improvement over previous drugs is that it is longer lasting and ambien lunesta may help insomniacs sleep through the night. Reductions in latency to persistent sleep and number of ambien lunesta awakenings were not statistically significant versus placebo. For more on the sleep market, see Sleeping Giants, page 58. SIEGEL SEPRACOR HAS shifted its Lunesta DTC advertising business from McCann Erickson to Kaplan Thaler Group. No evidence of tolerance or dependence has been reported. Marc Siegel, MD, is an internist and associate professor Ambien lunesta of medicine at New York University and the author of False Alarm: The Truth About the Epidemic of Fear. * Pfizer and AstraZeneca with the Got Cholesterol campaign for Lipitor and Crestor, which Community Catalyst pronounced me-too drugs. * Lilly with the Driven to Distraction Award for Strattera, which a spokesman for the group said promoted a product designed ambien lunesta to help consumers who are highly distractable by distracting them. * PhRMA with the Fox Guarding the Henhouse Award and the Truth Is Stranger Than ambien lunesta fiction Award for its DTC guidelines and an aborted publishing venture, respectively. As the April launch date approached, Sepracor ramped up ambien lunesta its U. -based, primary care and specialty-oriented sales force of 450. Patients reported results once weekly through an interactive voice response system and completed monthly study visits for safety and compliance assessments. Sepracor faced the world’s thirdlargest drug company in SanofiAventis. The Finalists * Abelson-Taylor, Inc. Tolerability Unpleasant taste (34 versus 3 percent), headache (17 versus 13 percent), and dizziness ambien lunesta (7 versus 4 percent) were reported more commonly in patients taking eszopiclone than those taking placebo, respectively, in clinical trials. Ambien lunesta ambien hovered close to 80 percent throughout. The firm stressed that while somnambulism may occur during treatment with Ambien, it may not necessarily be caused by it and that the drug is safe when taken as prescribed. 2, heading off ambien lunesta congressional action with industry self-regulation. (2) Safety The duration of action of eszopiclone is approximately eight hours, similar to zolpidem (Ambien) and longer Ambien lunesta than zaleplon (Sonata). The effect on sleep was maintained but attenuated; at six months, eszopiclone-treated patients fell asleep approximately 16 minutes faster, had 0. 7 fewer nighttime awakenings, and slept 39 minutes longer Ambien lunesta than placebo-treated patients. Like its older cousins, Ambien and Sonata, Lunesta is a hypnotic sleep drug that isn’t addictive and doesn’t require larger and larger doses. Lundbeck in partnership with Merck.