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To prevent a potentially fatal reaction, do not use an antidepressant if you have taken a monoamine oxidase inhibitor within the last 14 days. It’s 14 years later, and finally the FDA — albeit tentatively — is doing lexapro paxil prozac zoloft the right thing, said Dr. Please do send me your results! A column devoted to informative integrative health resources on the Internet by Marjorie Roswell mroswell@gmail. Com Health/Medical Writers BELLEVUE, Wash. –(BUSINESS WIRE)–March 31, 2003 Risk for suicide does not increase when taking commonly prescribed antidepressants called SSRIs (Prozac, Zoloft, Paxil, Celexa and Lexapro) compared to other antidepressants or placebo according to data comparing incidence of suicides in studies assessing new antidepressants. Detailed psychiatric evaluation and management are warranted for suicidal patients. Arif Khan, MD Medical Director, Northwest Clinical Research Center Adjunct Associate Professor, Psychiatry Duke University Medical Center 425/453-0404 email: akhan@nwcrc. NetThe FDA has called on manufacturers of 10 antidepressants to change their labeling to include recommendations that clinicians, families and caregivers closely monitor patients for worsening depression and suicidal thinking. However, they are safer and less likely to lexapro paxil prozac zoloft interact with other drugs, Dr. Antidepressants also are used to treat anxiety disorders (which often coexist with depression) lexapro paxil prozac zoloft and certain pain syndromes, such as fibromyalgia. David Healy, director of the North Wales Department of Psychological Medicine, estimates that 18 million Americans take Paxil, Zoloft and Prozac each year and as many as 30 million take some kind of antidepressant. Matthew Rudorfer, the National Institute of Mental Health psychiatrist who chairs the FDA advisory panel, said lexapro paxil prozac zoloft the group did not believe that the risks of the medications ruled out their use. Effexor, Cymbalta, and Remeron, a newer group of antidepressants, boost brain levels of serotonin and norepinephrine, like the tricyclics. Although it is not yet clear whether antidepressants contribute to suicidal thinking and behavior, the FDA is advising health care providers that worsening symptoms could be due either to the underlying disease or to drag therapy. The 10 drugs — Prozac, Zoloft, Paxil, Luvox, Celexa, Lexapro, Effexor, Wellbutrin, Serzone and Remeron — are taken by an estimated 30 million Americans each year. The FDA said that patients should be monitored especially lexapro paxil prozac zoloft carefully at the beginning of treatment and when the doses are changed — either increased or decreased. * Anxiety, agitation, panic attacks, lexapro paxil prozac zoloft insomnia, irritability, hostility, impulsivity, akathisia (severe restlessness). Minimize alcohol use with any antidepressant, and tell your doctor and pharmacist about all medicines and supplements you take. If you’re taking one of the most lexapro paxil prozac zoloft commonly prescribed anti-depressant drugs, your doctor may begin monitoring you more closely for signs that your depression is worsening, especially when you begin the therapy or your dosage is changed. Depression is a serious public health issue — and it takes great courage for patients to begin treatment in the first place, said Jennifer Yoder, Eli Lilly and Co. According to the company, Vioxx is the first and only COX-2 specific inhibitor approved to treat migraines. (For details refer to American Journal of Psychiatry, April 2003 issue, Suicide Rates in Clinical Trials of SSRIs, Other Antidepressants, and Placebo: Analysis of FDA Reports) We found that frequency of suicidal death was not significantly different among the three treatments; SSRIs, non-SSRIs, and placebo, Khan stated. Nor were the methods committing suicide different among those given three different treatments. No homicides were noted among these depressed patients. Despite the new advisory, don’t stop taking your antidepressant. They compared the incidence lexapro paxil prozac zoloft of suicide in patients taking SSRIs, antidepressants not designated to be SSRIs and those taking placebo or the ’sugar pill’.